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  • Previous fetus/child with a congenital, genetic, or chromosomal abnormality

  • Known or suspected fetal anomaly or growth disorder in current pregnancy

  • Fetus at increased risk for a congenital anomaly, such as the following:

    • Maternal pre-gestational diabetes, or gestational diabetes diagnosed before 24 weeks’ gestation

    • Pregnancy conceived via assisted reproductive technology

    • High maternal body mass index

    • Multiple gestations

    • Abnormal maternal serum analytes, including a-fetoprotein level and unconjugated estriol

    • Teratogen exposure

    • First-trimester nuchal translucency measurement of 3.0 mm or greater

  • Fetus at increased risk for a genetic or chromosomal abnormality, such as the following:

    • Parental carrier of a chromosomal or genetic abnormality

    • Maternal age of 35 years or older at time of delivery

    • Positive aneuploidy test, including non-invasive prenatal testing

    • Soft marker for aneuploidy on ultrasound

  • Other conditions affecting the fetus, including the following:

    • Congenital infections

    • Maternal drug dependence

    • Alloimmunization or Isoimmunization

    • Oligohydramnios or Polyhydramnios

  • Suspected placenta PAC or risk factors for PAS such as placenta previa in the third trimester or a placenta overlying a prior Cesarean scar site

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